Analyzing polar compounds using liquid chromatography has historically been a challenge due to poor retention, long equilibration times, low sensitivity, and the need to mitigate these problems with time-consuming sample derivatization or complex ion-pairing approaches. However, with the development of the Raptor Polar X column—a novel column that is specifically designed for the analysis of a broad range of polar compounds—scientists can avoid these problems. These new columns feature a unique phase chemistry that combines both HILIC and ion-exchange retention mechanisms on a single ligand. Because this ligand is bound to superficially porous particles, Raptor Polar X columns both reliably retain and efficiently separate a wide variety of polar analytes with simple mobile phase changes. By analyzing polar compounds on a column that provides purpose-built resolving power, you can avoid complex sample preparation procedures, save time and money, and reduce opportunities for error. Simplify the analysis of polar compounds with the resolving power of Raptor Polar X columns from Restek.